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M.Sc. Tillmann Wiegold

M.Sc. Tillmann Wiegold Foto von M.Sc. Tillmann Wiegold

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(+49)231 755-7902

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Raum 149

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Institute of Mechanics

Department of Mechanical Engineering

TU Dortmund

Leonhard-Euler-Strasse 5

D-44227 Dortmund

Inhalt

CURRICULUM VITAE

Education & Professional Experience

Since 03/2018 Research Assistant, Institute of Mechanics, TU Dortmund, Germany
08/2016-02/2018 M. Sc. in Mechanical Engineering, TU Dortmund, Germany
Thesis: "On phase field modeling of ductile damage"
10/2011-08/2016 B. Sc. in Mechanical Engineering, TU Dortmund, Germany
Thesis: "Gradientenerweiterung eines Schädigungsmodells"
07/2016-02/2018 Student Assistant, Institute of Mechanics, TU Dortmund, Germany


RESEARCH

D-A-CH Project (DFG, FWF) - Computational Modeling of Vesicle-Mediated Cell Transport  (CM-TransCell)
(Start: March 2018)
PIs: S. Klinge and G. A. Holzapfel
Coworkers: T. Wiegold and D. Haspinger

The particularly important characteristics of eukaryotic cells are the enormous complexity of their membrane anatomy and the high level of organization of the transport processes. The surprisingly precise manner of the routing of vesicles to various intracellular and extracellular destinations can be illustrated by numerous examples such as the release of neurotransmitters into the presynaptic region of a nerve cell and the export of insulin to the cell surface.

The key idea of the present project is to couple results of biomedical investigations and mechano-mathematical models with the highly efficient engineering software packages in order to simulate this type of processes, in particular the vesicle transport. The results should bridge the theoretical investigations and medical praxis and shift the paradigm in understanding and remedying different diseases, which certainly is the primary and long-term goal of the project. The individual objectives coincide with the modeling of single aspects of the vesicle transport, namely with the simulation of mechanisms by which the vesicles form, find their correct destination, fuse with organelles and deliver their cargo. The application of several different approaches is envisaged for this purpose, but three main strategies build the underlying skeleton: the theory of lipid bilayer membranes, the homogenization method and the diffusion theory. The mentioned approaches will furthermore be combined with the modern numerical techniques such as the finite element method and the multiscale finite element method.

In the final stage, the realization of single objectives will allow the simulation of vesicle transport as a continuous process and the study of the impact of various factors on the whole process. This way, the project will yield a significant shift from "static" bio-computations related to the single cell compartments and substeps of its activities, to the "dynamic" simulation of the real living processes.


Publications

Publications in journals (reviewed)

Talks

  • Viscoelsaticity of cross-linked actin network embedded in cytosol
    89th GAMM Annual Meeting, Munich, Germany, March 19-23, 2018

Contributions in books and in proceeding books

  • M. Awd, S. Siddique, J. Johannsen, T. Wiegold, S. Klinge, C. Emmelmann, F. Walther, 2018
    Quality assurance of additively manufactured alloys for aerospace industry by non-destructive testing and numerical modeling,
    Proceedings of the 10th International Conference on Non-destructive Testing in Aero-space (2018) 1-10