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Institute of Mechanics

Department of Mechanical Engineering

TU Dortmund

Leonhard-Euler-Strasse 5

D-44227 Dortmund

CURRICULUM VITAE

Education & Professional Experience

RESEARCH

D-A-CH Project (DFG, FWF) - Computational Modeling of Vesicle-Mediated Cell Transport  (CM-TransCell)
(Start: March 2018)
PIs: S. Klinge and G. A. Holzapfel
Coworkers: T. Wiegold and D. Haspinger

The particularly important characteristics of eukaryotic cells are the enormous complexity of their membrane anatomy and the high level of organization of the transport processes. The surprisingly precise manner of the routing of vesicles to various intracellular and extracellular destinations can be illustrated by numerous examples such as the release of neurotransmitters into the presynaptic region of a nerve cell and the export of insulin to the cell surface.

The key idea of the present project is to couple results of biomedical investigations and mechano-mathematical models with the highly efficient engineering software packages in order to simulate this type of processes, in particular the vesicle transport. The results should bridge the theoretical investigations and medical praxis and shift the paradigm in understanding and remedying different diseases, which certainly is the primary and long-term goal of the project. The individual objectives coincide with the modeling of single aspects of the vesicle transport, namely with the simulation of mechanisms by which the vesicles form, find their correct destination, fuse with organelles and deliver their cargo. The application of several different approaches is envisaged for this purpose, but three main strategies build the underlying skeleton: the theory of lipid bilayer membranes, the homogenization method and the diffusion theory. The mentioned approaches will furthermore be combined with the modern numerical techniques such as the finite element method and the multiscale finite element method.

In the final stage, the realization of single objectives will allow the simulation of vesicle transport as a continuous process and the study of the impact of various factors on the whole process. This way, the project will yield a significant shift from "static" bio-computations related to the single cell compartments and substeps of its activities, to the "dynamic" simulation of the real living processes.

Publications

Publications in journals (reviewed)

• S. Aygün, T. Wiegold and S. Klinge, 2021
  Coupling of the phase field approach to the Armstrong-Frederick model for the simulation of ductile damage under cyclic load,
  Int. J. Plast., DOI: 10.1016/j.ijplas.2021.103021

• T. Wiegold, S. Klinge, R. P. Gilbert and G. A. Holzapfel, 2021
  Numerical simulation of the viral entry into a cell driven by the receptor diffusion,
  Comput. Math. Appl., 84, 224-243, DOI: 10.1016/j.camwa.2020.12.012, preprint

• S. Siddique, M. Awd, T. Wiegold, S. Klinge, F. Walther, 2018
  Simulation of cyclic deformation behavior of selective laser melted and hybrid-manufactured aluminum alloys using the phase-field method,
  Applied Sciences 8(10), 1948 (2018) 1-18, DOI: 10.3390/app8101948

Talks

• Numerical simulation of low cycle fatigue behavior, combining the phase-field method and the Armstrong-Frederick model
  91st GAMM Annual Meeting, Kassel, Germany, March 15-19, 2021

• The influence of binder mobility to the viral entry driven by the receptor diffusion
  4th International Conference on Biomedical Technology, Hannover, Germany, November 18-20, 2019

• Numerical simulation of the viral entry into a cell by receptor driven endocytosis
  8th GACM Colloquium on Computational Mechanics, Kassel, Germany, August 28-30, 2019

• Computational modeling of adhesive contact between a virus and a cell during receptor driven endocytosis
  90th GAMM Annual Meeting, Vienna, Austria, February 18-22, 2019

• Viscoelsaticity of cross-linked actin network embedded in cytosol
  89th GAMM Annual Meeting, Munich, Germany, March 19-23, 2018

Contributions in books and in proceeding books

• S. Klinge, T. Wiegold, S. Aygün, R. P. Gilbert and G. A. Holzapfel, 2021
  Numerical modeling of the receptor driven endocytosis,
  PAMM, 21, 1, e202100142

• T. Wiegold, S. Aygün, S. Klinge, 2021
  Numerical simulation of low cycle fatigue behavior, combining the phase-field method and the Armstrong-Frederick model,
  PAMM, 21, 1, e202100111

• S. Klinge, T. Wiegold, S. Aygün, R. P. Gilbert and G. A. Holzapfel, 2020
  On the modeling of cell components,
  PAMM, 20, 1, e202000129

• T. Wiegold and S. Klinge, 2020
  Numerical simulation of cyclic deformation behavior of SLM-manufactured aluminum alloys,
  PAMM, 20, 1, e202000181

• T. Wiegold, S. Klinge, R. P. Gilbert and G. A. Holzapfel, 2019
  Computational modeling of adhesive contact between a virus and a cellduring receptor driven endocytosis,
  PAMM, 19, 1, e201900161

• T. Wiegold, S. Klinge, R. P. Gilbert and G. A. Holzapfel, 2019
  Numerical simulation of the viral entry into a cell by receptor driven endocytosis,
  Proceedings of 8th GACM Colloquium on Computational Mechanics, 401-404

• T. Wiegold, S. Klinge, S. Aygün, R. P. Gilbert, G. A. Holzapfel, 2018
  Viscoelasticity of Cross-Linked Actin Network Embedded in Cytosol,
  PAMM, 18, 1, e201800151

• M. Awd, S. Siddique, J. Johannsen, T. Wiegold, S. Klinge, C. Emmelmann, F. Walther, 2018
  Quality assurance of additively manufactured alloys for aerospace industry by non-destructive testing and numerical modeling,
  Proceedings of the 10th International Conference on Non-destructive Testing in Aero-space (2018) 1-10

• S. Klinge, T. Wiegold, G. A. Holzapfel and R. P. Gilbert, 2017
  The influence of binder mobility on the viral entry into a cell,
  PAMM, 17.1, 197-198