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Biological tissue

A micro-sphere-based remodelling formulation for transversely isotropic soft biological tissue



Soft biological tissues possess a pronounced composite-type multi-scale structure together with strongly anisotropic mechanical properties. A fibre-like network structure is characteristic for this kind of materials. If the tissue will be exposed to mechanical loading, an initially unstructured collagen fibre network tends to reorient with the local dominant stretch direction – it adapts according to the particular loading conditions. In general, biological tissues exhibit changes in mass, which is denoted as growth, and changes in internal structure, which is commonly referred to as remodelling. In this regard, an anisotropic micromechanically motivated model that incorporates this time-dependent remodelling effect will be introduced here.